Anti-FCRLA immunotoxin E9 (IgG)-PE
Anti-FCRLA immunotoxin E9 (IgG)-PE
This immunotoxin was achieved by conjugating/fusing the Anti-FCRLA monoclonal antibody to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to FCRLA expressed B-cell malignancies cells. Once bind, the toxin enters cells by receptor-mediated endocytosis. Then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for treating mixed cryoglobulinemia (MC) vasculitis and B cell non-Hodgkin's lymphoma. http://www.creativebiolabs.net/Anti-FCRLA-IgG-PE-immunotoxin-17121.htm
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